How do statin drugs lower the risk of cardiovascular disease (CVD)? Two answers are correct. Question 2 options: Statin drugs inhibit COX-2, which is responsible for inflammation in cholesterol plaques in blood vessels, this in turn shrinks plaques. Statin drugs block uptake of cholesterol in the intestine and thereby decrease the risk of CVD. Statin drugs stimulate the synthesis of HDL particles in adipocytes, and since HDL is “good cholesterol,” this lowers the risk of CVD. Statin drugs increase uptake of LDL particles into liver cells, which lowers circulating LDL in the blood. Statin drugs decrease the level of LDL receptors on liver cells and this is associated with reduced risk of CVD. Statin drugs inhibit cholesterol biosynthesis in the liver, which stimulates expression of LDL receptors on the surface of liver cells. Statin drugs lower the risk of CVD by increasing the size of the cholesterol ester pool in endothelial cells, which lowers LDL levels in the blood. Statin drugs inhibit the enzyme HMG-CoA reductase, which decreases cholesterol levels in the liver so it does not leak out into the blood.