Genome-wide Association Studies (GWAS) hold considerable promise


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Genome-wide Association Studies (GWAS) hold considerable promise as a method to uncover the causative genes for complex human genetic diseases (e.g., many cancers, coronary heart disease, hypertension, depression, schizophrenia, etc.) for which heritability is significant but there is no obvious Mendelian locus underlying the disease state. a) Outline the basic premise of a GWAS b) Do you think a GWAS is more likely to uncover a causative locus if it lies in a genomic region of high recombination or low recombination? Explain your reasoning.

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